Isomerization of Asp residues plays an important role in αA-crystallin dissociation
نویسندگان
چکیده
منابع مشابه
Kinetics of Isomerization and Inversion of Aspartate 58 of αA-Crystallin Peptide Mimics under Physiological Conditions
Although proteins consist exclusively of L-amino acids, we have reported that aspartyl (Asp) 58 and Asp 151 residues of αA-crystallin of eye lenses from elderly cataract donors are highly inverted and isomerized to D-β, D-α and L-β-Asp residues through succinimide intermediates. Of these Asp isomers, large amounts of D-β- and L-β-isomers are present but the amount of D-α-isomer is not significa...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2016
ISSN: 1742-464X
DOI: 10.1111/febs.13635